HDAC


HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDACs, are classified in four classes depending on sequence homology to the yeast original enzymes and domain organization:class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11).
  • Sodium Phenylbutyrate EY0455

    Sodium phenylbutyrate (NaPB), a derivative of the short-chain fatty acid butyrate, is a low-potency histone deacetylase inhibitor and originally approved for treatment of UCD. Sodium Phenylbutyrate是一种转录调节因子,通过调控HDAC活性来改变染色质结构从而发挥作用,是组蛋白脱乙酰酶(HDAC)抑制剂,IC50为1-5 uM。

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  • Entinostat EY0413

    Entinostat (MS-27-275, MS-275, SNDX-275) an orally class I histone deacetylase (HDAC)-specific inhibitor, is currently in clinical trials.

    More
  • Rocilinostat EY0391

    Ricolinostat (ACY-1215) is an oral, first-in-class, selective inhibitor of HDAC6, and inhibits tubulin deacetylase. Rocilinostat (ACY-1215)是高效HDAC6抑制剂,IC50为5 nM,比对HDAC1/2/3的抑制性高10倍以上,对HDAC8有微弱活性,对HDAC4/5/7/9/11,Sirtuin1和Sirtuin2活性最低。

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  • SAHA EY0003

    Vorinostat (SAHA, MK0683)是一种I和II类组蛋白去乙酰化酶(HDAC)抑制剂,IC50小于86 nM。

    More
  • Tasquinimod EY1756

    Tasquinimod(ABR-215050)是喹啉-3-甲酰胺利诺胺类似物,具有抗血管生成和抗肿瘤活性。

    More
  • Sodium Phenylbutyrate EY0455

    Sodium phenylbutyrate (NaPB), a derivative of the short-chain fatty acid butyrate, is a low-potency histone deacetylase inhibitor and originally approved for treatment of UCD. Sodium Phenylbutyrate是一种转录调节因子,通过调控HDAC活性来改变染色质结构从而发挥作用,是组蛋白脱乙酰酶(HDAC)抑制剂,IC50为1-5 uM。

    More
  • Entinostat EY0413

    Entinostat (MS-27-275, MS-275, SNDX-275) an orally class I histone deacetylase (HDAC)-specific inhibitor, is currently in clinical trials.

    More
  • Rocilinostat EY0391

    Ricolinostat (ACY-1215) is an oral, first-in-class, selective inhibitor of HDAC6, and inhibits tubulin deacetylase. Rocilinostat (ACY-1215)是高效HDAC6抑制剂,IC50为5 nM,比对HDAC1/2/3的抑制性高10倍以上,对HDAC8有微弱活性,对HDAC4/5/7/9/11,Sirtuin1和Sirtuin2活性最低。

    More
  • SAHA EY0003

    Vorinostat (SAHA, MK0683)是一种I和II类组蛋白去乙酰化酶(HDAC)抑制剂,IC50小于86 nM。

    More
  • Tasquinimod EY1756

    Tasquinimod(ABR-215050)是喹啉-3-甲酰胺利诺胺类似物,具有抗血管生成和抗肿瘤活性。

    More
  • Sodium Phenylbutyrate EY0455

    Sodium phenylbutyrate (NaPB), a derivative of the short-chain fatty acid butyrate, is a low-potency histone deacetylase inhibitor and originally approved for treatment of UCD. Sodium Phenylbutyrate是一种转录调节因子,通过调控HDAC活性来改变染色质结构从而发挥作用,是组蛋白脱乙酰酶(HDAC)抑制剂,IC50为1-5 uM。

    More
  • Entinostat EY0413

    Entinostat (MS-27-275, MS-275, SNDX-275) an orally class I histone deacetylase (HDAC)-specific inhibitor, is currently in clinical trials.

    More
  • Rocilinostat EY0391

    Ricolinostat (ACY-1215) is an oral, first-in-class, selective inhibitor of HDAC6, and inhibits tubulin deacetylase. Rocilinostat (ACY-1215)是高效HDAC6抑制剂,IC50为5 nM,比对HDAC1/2/3的抑制性高10倍以上,对HDAC8有微弱活性,对HDAC4/5/7/9/11,Sirtuin1和Sirtuin2活性最低。

    More
  • SAHA EY0003

    Vorinostat (SAHA, MK0683)是一种I和II类组蛋白去乙酰化酶(HDAC)抑制剂,IC50小于86 nM。

    More
  • Tasquinimod EY1756

    Tasquinimod(ABR-215050)是喹啉-3-甲酰胺利诺胺类似物,具有抗血管生成和抗肿瘤活性。

    More
  • Sodium Phenylbutyrate EY0455

    Sodium phenylbutyrate (NaPB), a derivative of the short-chain fatty acid butyrate, is a low-potency histone deacetylase inhibitor and originally approved for treatment of UCD. Sodium Phenylbutyrate是一种转录调节因子,通过调控HDAC活性来改变染色质结构从而发挥作用,是组蛋白脱乙酰酶(HDAC)抑制剂,IC50为1-5 uM。

    More
  • Entinostat EY0413

    Entinostat (MS-27-275, MS-275, SNDX-275) an orally class I histone deacetylase (HDAC)-specific inhibitor, is currently in clinical trials.

    More
  • Rocilinostat EY0391

    Ricolinostat (ACY-1215) is an oral, first-in-class, selective inhibitor of HDAC6, and inhibits tubulin deacetylase. Rocilinostat (ACY-1215)是高效HDAC6抑制剂,IC50为5 nM,比对HDAC1/2/3的抑制性高10倍以上,对HDAC8有微弱活性,对HDAC4/5/7/9/11,Sirtuin1和Sirtuin2活性最低。

    More
  • SAHA EY0003

    Vorinostat (SAHA, MK0683)是一种I和II类组蛋白去乙酰化酶(HDAC)抑制剂,IC50小于86 nM。

    More
  • Tasquinimod EY1756

    Tasquinimod(ABR-215050)是喹啉-3-甲酰胺利诺胺类似物,具有抗血管生成和抗肿瘤活性。

    More
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